Rare anaemias

Rare anaemias are a group of genetic conditions which cause the person to not be able to produce red cells effectively, or the red cells they produce may be faulty and destroyed by the body sooner than they should be. Either of these problems results in the person being anaemic. Some people with rare anaemias require regular blood transfusions to control their symptoms.

Some examples of rare anaemias include:

  • Congenital dyserythropoetic anaemia (CDA) type 1 and 2
  • Diamond Blackfan anaemia
  • PK (pyruvate kinase) deficiency
  • Hereditary spherocytosis

Some people with rare anaemias have a haemolytic anaemia. This means that the body is destroying the blood sooner than it would normally. This can result in the spleen becoming enlarged, and the person can be jaundiced.

Please note that this page is for general information only. This is not clinical advice and should not be used for clinical decision making. Every effort is taken to keep this content up to date, but we cannot guarantee that all content is accurate and current at the time of reading. 

Picture of haemolysis

Treatments vary depending on the underlying condition, but may include:

  • Regular blood transfusions
  • Splenectomy (removing the spleen) if the person has haemolytic anaemia
  • Folic acid tablets to support the body as it makes more red blood cells
  • Iron chelation – this is medicine (either tablets or injection) which removes the extra iron from the body when having long term blood transfusions.

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